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Knowledge intensive industries and innovative socio-economic activities tend to cluster in cities, creative hubs and high-tech zones. This can generate territorial disparities and the need for local and regional strategies to generate learning opportunities, link to existing hubs and value chains, and build on local strengths and opportunities. INGENIO contributes to the debate on the challenges for peripheral areas in Europe, and to addressing the need for coordinated and appropriate knowledge and innovation strategies at local and regional levels